I tend to defer from using those when I can just use the person’s name or the ungendered pronouns. To me, when I see those besides someone’s name, it just means that they don’t want to be labeled as any gender.

Though, on that note. I honestly never really understood the purpose of people using zhey/zhem/zheir when they/them/their is already neutral.

I would totally use xe/xer if doing so wouldn’t be hugely distracting from whatever topic I’m actually talking about, those words have a nice scifi vibe to them.